Abstract
88 patients with thyrotoxicosis were seen over the past 21 yrs: the female/male ratio was 4:1. The ages ranged between 2 to 8 years. 28 patients were lost to follow-up and 60 were followed for an average of 3.9 yrs. Family history of thyroid disease was present in 23 patients and was thyrotoxicosis in 12. Of 28 patients (46%) who underwent sub-total thyroidectomy, 13 relapsed after an average of 3 years of medical treatment; 5 had hypersensitivity to Propylthiouracil; 11 showed poor cooperation. Prophylactic thyroid hormone was begun in 5 patients after surgery, and in an additional 8 because of subsequent hypothyroidism. Fourteen had permanent remission on medical treatment, three of whom may have had thyrotoxic thyroiditis. Of the series of 60, one child was referred after treatment with RAI131, and another died of other causes.
Fourteen patients on Propylthiouracil continue to be followed, and the longest duration of medical treatment has been 6 years in one patient. Our experience leads us to employ medical treatment for prolonged periods when there are no complications.
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Vaidya, V., Parks, J., Kirkland, R. et al. JUVENILE THYROTOXICOSIS. Pediatr Res 8, 377 (1974). https://doi.org/10.1203/00006450-197404000-00220
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DOI: https://doi.org/10.1203/00006450-197404000-00220