Abstract
Children (ages 3-16) with expected low incidence of vascular disease should be ideal subjects for studying the relationship between carbohydrate (CHO) intolerance and vascular abnormalities in the pathogenesis of DM. 56 K values were determined by IV glucose tolerance test (IVGTT) in 17 diabetic and 31 control (C) children (most C had a family history of DM). BMT was measured in 17 diabetics and 17 controls.
K values for diabetics were 0.82±0.50 (mean±SD) and for C group 1.84±0.70 P<0.001. BMT in the diabetics (1844±320Å) did not differ significantly from that in C (1581±495Å) but in both groups increased BMT was associated with evidence of CHO intolerance. Of 11 patients with BMT > 1800Å, 10 had K <1.2, and all had high (>110mg%) 60' plasma glucose (60PG). 60PG may be a sensitive index of CHO intolerance, as suggested by the following; (a) 3 C with high 60PG and no DM in the family consented to oral GTT; all were markedly abnormal, (b) 11 IVGTT on 4 C born of conjugal diabetics yielded high 60PG although K were always >1.2.
Plasma I and GH response to IVGTT and duration of DM did not correlate with BMT. 5 patients with DM had normal BMT, which suggests that CHO abnormalities precede increased BMT.
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Sheikholislam, B., Lin, HJ., Stephenson, S. et al. PATHOGENESIS OF DIABETES MELLITUS (DM): CAPILLARY BASEMENT MEMBRANE THICKNESS (BMT), GLUCOSE DISPOSAL RATE (K), PLASMA INSULIN (I), AND GROWTH HORMONE (GH) IN CHILDREN. Pediatr Res 8, 375 (1974). https://doi.org/10.1203/00006450-197404000-00210
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DOI: https://doi.org/10.1203/00006450-197404000-00210