Abstract
Typically, patients with male pseudohermaphroditism due to complete androgen insensitivity (MP-CAI) feminize at puberty (Testicular feminization). However, male pseudohermaphrodites with partial masculinization of the external genitalia may feminize or masculinize at puberty.
A highly specific low capacity DHT binding protein has been identified in the fibroblasts cultured from skin explants of normal males and females. The binding capacity (Bmax) and apparent dissociation constant (Kd) were determined by linear regression analysis of a double reciprocal plot of a saturation curve (see table). Similar binding activity is present in the fibroblasts from MP-VP but is not present in those who have MP-CAI and feminize at puberty. The specific DHT binding activity in cultured skin fibroblasts seem to be a useful tool in distinguishing and characterizing some types of male pseudohermaphrodites.
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Meyer, W., Keenan, B., Park, J. et al. DIHYDROTESTOSTERONE (DHT) BINDING ACTIVITY OF CULTURED SKIN FIBROBLASTS FROM FAMILIAL MALE PSEUDOHERMAPHRODITES WITH VIRILIZATION AT PUBERTY (MP-VP). Pediatr Res 8, 372 (1974). https://doi.org/10.1203/00006450-197404000-00190
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DOI: https://doi.org/10.1203/00006450-197404000-00190