Abstract
The citrate load in exchange transfusion (ET) performed with donor blood preserved with acid-citrate and dextrose causes a sharp fall in plasma ionized calcium (I.C. Radde et al. Ped.Res.6,43 (1972). PTH secretion during ET was studied by measuring plasma PTH, Ca, PO4, citrate and albumen in the donor blood and in the infant during the procedure. Donor plasma PTH was 164 ± 46 pg/ml, significantly lower than that in the baby, 728 ± 134 pg/ml (n = 18). During the ET the infant's plasma PTH remained steady or rose slightly indicating increased secretion of PTH. Infants studied more than once had increasing PTH secretion with postnatal age or a high steady PTH secretion. ET caused a large net positive balance of citrate and significant negative balances of PTH, Ca and PO4.
The results show that the newborn erythroblastotic infant is able to respond to a fall in plasma ionized calcium with increased PTH secretion and that, in some infants, this response develops in early postnatal life.
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Milner, R., Woodhead, J. PTH SECRETION IN EXCHANGE TRANSFUSION. Pediatr Res 8, 128 (1974). https://doi.org/10.1203/00006450-197402000-00011
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DOI: https://doi.org/10.1203/00006450-197402000-00011