Abstract
In an attempt to define parameters of prognostic value, catheterization studies were performed in 10 infants with severe RDS & PDA who were considered candidates for closure of the PDA because of congestive heart failure, a continuous murmur, & left ventricular hypertrophy on EKG. Birth wts. were 800-1860 gms. PDA murmurs were noted at 3-21 days, & catheterizations were performed at 33-120 days of age. Angiography confirmed the PDA & ruled out other shunts. Qs, Qp, & L→R shunts were measured by cardiogreen dye curves, FA.& PA mean pressures were 56 & 34 mmHg. Mean values for Qs & Qp were 1.8 & 4.4 L/min/M2. AaDO2 levels were variable. aADCO2 levels >10 mmHg were associated with severe lung disease and/or pulmonary edema. 9/10 infants had ductal shunts ≥55%. One pt. had negligible L→R shunt and later died of bronchopulmonary dysplasia (BPD). Six infants underwent surgery successfully; 3 improved and 3 were unchanged (2 later died of BPD). In the 3 remaining nonoperated patients, 2 improved spontaneously & 1 died suddenly before operation. Postoperative improvement in aADCO2 levels provided retrospective confirmation of benefits of ligation of the PDA in the 3 improved pts. No hemodynamic parameters correlated with results in these infants.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bessinger, F., Neal, W., Hunt, C. et al. CATHETERIZATION AND PULMONARY FUNCTION STUDIES IN 10 INFANTS WITH RESPIRATORY DISTRESS SYNDROME (RDS) AND PATENT DUCTUS ARTERIOSUS (PDA). Pediatr Res 8, 347 (1974). https://doi.org/10.1203/00006450-197404000-00043
Issue Date:
DOI: https://doi.org/10.1203/00006450-197404000-00043