Abstract
Thromboembolism is a rare but often serious and sometimes fatal complication of the nephrotio syndrome in childhood. An inquiry amongst the members of the ESPN and other European paediatric nephrologists disclosed 60 patients (1.8%) with thromboembolic complications of 3377 children with a nephrotic syndrome during 1962 - 1971. We reviewed anamnestic and clinical as well as pathological-anatomical findings and laboratory data from 56 of these patients.
Thromboembolism may be localized in almost any part of the circulation. The histological examination of the kidneys of 48 patients showed predominantly minimal changes (26 cases) or focal glomerular lesions (15 cases). The children are especially susceptible to this complication during the active phase of the N.S.(22 patients with first manifestation of the disease, 33 cases during relapse) while having generalized massive edema (33 patients). As most of these children have received steroid treatment somewhere during the course of their disease, it is not possible to exclude the possibility, that steroids play an etiological role for this complication. Immobilization and secondary infections as well as hypertension and azotaemia do not seem to be an important predisposing factor.
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Egli, F., Elmiger, P. & Stalder, G. Thromboembolism in the Nephrotic Syndrome. Pediatr Res 8, 903 (1974). https://doi.org/10.1203/00006450-197411000-00049
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DOI: https://doi.org/10.1203/00006450-197411000-00049
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