Abstract
Total complement (CH50) and C1-C9 have been determined in sera and urines of rats with NSN and AN. In NSN, 3 hrs. after injection of antiserum, a significant drop of CH50 and C1-C8 in serum was observed, whereas C9 remained normal. At day 12 CH50 and the complement factors were normal except C1, which was still slightly diminished. In urine, at day 1 only C8 and C9, at day 12 small amounts of C1,C4,C8 and C9 and, less frequently, of C3-C7 could be measured. In AN, at day 12 CH50 and C1-C9 were strikingly diminished in serum. In urine, at day 12 C3,C5,C7,C8 and C9 could be determined regularly, whereas urinary excretion of C1,C4,C2 and C6 was observed in about 50% of the animals. In NSN, the consumption of complement in serum reflects the ongoing immunological process. The low clearances of complement components, compared to AN, may be due to their fixation and inactivation in the kidney. In AN, the reduction of complement in serum may be the result of loss of complement factors in oedema, ascites and urine, and/or of impaired synthesis of these proteins.
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Geiger, H., Good, R., Day, N. et al. Complement studies in nephrotoxic serum nephritis (NSN) and aminonucleoside nephrosis (AN) of the rat. Pediatr Res 8, 901 (1974). https://doi.org/10.1203/00006450-197411000-00041
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DOI: https://doi.org/10.1203/00006450-197411000-00041