Abstract
Plasma antihemophilic globulin (AHG) activity normally increased after vigorous exercise. Eleven normal women and nine mothers of patients with hemophilia A were studied before and immediately after a 10 minute, standardized and strenuous exercise load. In the normal group pre-exercise AHG levels ranged from 48–112% with a mean of 88%; after exercise the mean value was 168% with a range of 100–400%. In the hemophilic carriers the mean pre-exercise level was 49% with a range of 27–79%; after exercise the mean value was 68% with a range of 50–100%.
In 10/11 controls post-exercise AHG levels exceeded 120% whereas in 8/6 carriers the post-exercise levels were less than 80%. Three carriers had AHG levels in the normal range, 66%, 69% and 79%; following exercise values found were 78%, 68% and 100% respectively. Three control had similar pre-exercise levels of 78%, 78% and 48%; however, following exercise these rose to 128%, 128% and 180% respectively, values significantly greater than the carrier group.
These data suggest that the mothers of patients with hemophilia A have a limited AHG response to exercise, a finding which may be of value in the detection of the hemophilia A carrier state.
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Luke, KH., Taylor, A., Hirsh, J. et al. Antihemophilic globulin (AHG) response to exercise for the detection of hemophilia A carriers. Pediatr Res 5, 409 (1971). https://doi.org/10.1203/00006450-197108000-00157
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DOI: https://doi.org/10.1203/00006450-197108000-00157