The ToRCH complex-perinatal infections associated with toxoplasma and rubella, cytomegol- and herpes simplex viruses

Abstract

It is difficult in most cases to differentiate clinically among perinatal infections associated with Toxoplasma (To), Rubella (R), Cytomegalovirus (C) and Herpes simplex virus, type 1 or 2 (H). To evaluate this problem, sera submitted to CDC from infants (<2 yrs.) with various abnormalities were tested for all agents in the ToRCH complex, besides those requested by the physician. Antibodies to To, R and C were measured by conventional technics, and antibodies to H type 1 and 2 by microneutralization and IgM fluorescent antibody tests. Interpretation of results were complicated by such factors as prior immunization, blood transfusions and the possible acquisition of antibodies either transplacentally or from a postnatal infection. Nevertheless, serological findings suggested perinatal infection with the ToRCH agents in 61 of 192 cases (37%). The type of involvement associated with individual agents is presented in the table: