Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

The ToRCH complex-perinatal infections associated with toxoplasma and rubella, cytomegol- and herpes simplex viruses

Abstract

It is difficult in most cases to differentiate clinically among perinatal infections associated with Toxoplasma (To), Rubella (R), Cytomegalovirus (C) and Herpes simplex virus, type 1 or 2 (H). To evaluate this problem, sera submitted to CDC from infants (<2 yrs.) with various abnormalities were tested for all agents in the ToRCH complex, besides those requested by the physician. Antibodies to To, R and C were measured by conventional technics, and antibodies to H type 1 and 2 by microneutralization and IgM fluorescent antibody tests. Interpretation of results were complicated by such factors as prior immunization, blood transfusions and the possible acquisition of antibodies either transplacentally or from a postnatal infection. Nevertheless, serological findings suggested perinatal infection with the ToRCH agents in 61 of 192 cases (37%). The type of involvement associated with individual agents is presented in the table:

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Nahmias, A., Walls, K., Stewart,, J. et al. The ToRCH complex-perinatal infections associated with toxoplasma and rubella, cytomegol- and herpes simplex viruses. Pediatr Res 5, 405–406 (1971). https://doi.org/10.1203/00006450-197108000-00144

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1203/00006450-197108000-00144

Further reading

Search

Quick links