Abstract
Berger (Transpl. Proc. 1:939, 1969) described a group of 55 patients who had divergent glomerular lesions by light microscopy, but by immunofluorescence had mesangial deposits of IgG, IgA and βlC-globulin. Most of the patients had a slowly progressive nephritis characterized by persistent microhematuria and mild proteinuria. Nephrotic syndrome was absent. Half of the patients had episodes of gross hematuria during a sore throat.
We have studied a group of 7 patients (ages 4–14 yrs) with mesangial deposits of IgG, IgA and β1C-globulin which by E. M. are located between mesangial cells and the glomerular basement membrane. Light microscopy revealed minimal increase in mesangial cellularity without matrix proliferation and an occasional mild focal lesion. Onset of disease was heralded by gross hematuria accompanying a respiratory infection and was followed by persistent microhematuria. Proteinuria was moderate with the gross hematuria and later diminshed or disappeared. At no time was hypocomplementemia or other signs of acute nephritis present. Initially many of the patients were considered to have benign recurrent hematuria but differed in that (1) they appeared to have respiratory infections with unusual frequency, each episode being accompanied by gross hematuria and (2) with time a persistent mild proteinuria developed in the absence of gross hematuria. In 3 patients the frequency of URI decreased and the microhematuria disappeared with prednisone therapy. Three patients not receiving prednisone and observed from 1 to 4 years had no evidence of progression of the lesion on repeat renal biopsy.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mcenery, P., McAdams, A. & West, C. Mesangial nephritis; an entity characterized by mesangial IgA-IgA depositis. Pediatr Res 5, 384 (1971). https://doi.org/10.1203/00006450-197108000-00056
Issue Date:
DOI: https://doi.org/10.1203/00006450-197108000-00056