Abstract
Total cardiopulmonary bypass was achieved in closed chest dogs. Systemic venous return (SVR) was directed through a recording electromagnetic flowmeter. Systemic arterial (SAP) and central venous pressure (CVP) were also monitored continuously. Alpha adrenergic agents caused a mean increase in SAP of 74% without any change in SVR. Beta adrenergic agents produced a mean fall of 34% in SAP and a mean increase of 9% in SVR and a mean increase of 4% in CVP. Alpha adrenergic blockage simulated beta adrenergic effect with a mean fall in SAP of 52% and mean increase of 8% in SVR and a mean increase of 3% in CVP. No significant changes occurred as a result of beta adrenergic blockade. These data demonstrate te dominent effect of the beta adrenergic nervous system in increasing systemic venous return by an increase in venomotor tone.
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Schieken, R., Peckham, G., Bilgic, A. et al. The Role of the Adrenergic Nervous System in Regulating Systemic Arterial Pressure and Venous Return. Pediatr Res 4, 444 (1970). https://doi.org/10.1203/00006450-197009000-00041
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DOI: https://doi.org/10.1203/00006450-197009000-00041