Abstract
Extract: The clinical finding of transient celluria in human infants experiencing perinatal asphyxia stimulated this experimental study on fetal and newborn rabbits. Both fetal and newborn rabbits, asphyxiated to the point of death, failed on recovery to excrete excessive numbers of epithelial cells in urine, whereas fetal rabbits, born of a doe that had been given 10% oxygen in nitrogen for 60 minutes, and newborn rabbits, given 5% oxygen in nitrogen for 70 to 90 minutes, excreted excessive numbers of cells in urine during the second to fourth day. This investigation supports the suggestion that perinatal hypoxia can lead to renal damage and reaffirms the need to differentiate epithelial cells from white blood cells in the urine of newborn infants.
Speculation: Prolonged perinatal asphyxia may cause renal damage. Occasionally, it is severe enough to cause acute renal failure in newborn infants. The possibility that it may cause chronic renal impairment should be explored.
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Tan, K., Hull, D. The Excretion of Cells in Urine Following Perinatal Asphyxia. Pediatr Res 3, 228–232 (1969). https://doi.org/10.1203/00006450-196905000-00007
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DOI: https://doi.org/10.1203/00006450-196905000-00007