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Polymer Structures

Studying the stereostructures of biomolecules and their analogs by vibrational circular dichroism

Polymer Journal volume 48, pages 925931 (2016) | Download Citation

Abstract

The functions of biomacromolecules are largely governed by their stereostructure (i.e., configuration and conformation). Therefore, detailed understanding of their structural properties should help in regulating the functions of artificial macromolecules. However, studying the stereostructure of a molecule in the solution state is typically difficult due to the lack of suitable analytical techniques. Vibrational circular dichroism (VCD) spectroscopy, which measures circular dichroism in the infrared region, exhibits high sensitivity toward molecular stereostructures. In this paper, we first discuss a method for the elucidation of the stereostructures of small to large molecules based on theoretical calculations of VCD. The rest of the paper is dedicated to the applications of a VCD exciton chirality method, a novel approach recently developed by the authors to interpret VCD data by observing a VCD couplet in the C=O stretching region, to various biomolecules such as peptides, carbohydrates, polyesters and lipids.

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Acknowledgements

TT acknowledges the financial support from the Japan Society for the Promotion of Science (JSPS) (nos. 23710244 and 26702034), the Shimadzu Science Foundation, the Akiyama Life Science Foundation and the Suhara Memorial Foundation.

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Affiliations

  1. Faculty of Advanced Life Science, Frontier Research Center for Post-Genome Science and Technology, Hokkaido University, Sapporo, Japan

    • Tohru Taniguchi
    • , Takahiro Hongen
    •  & Kenji Monde

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Competing interests

The authors declare no conflict of interest.

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Correspondence to Tohru Taniguchi.

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DOI

https://doi.org/10.1038/pj.2016.61

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