Abstract
Doxorubicin (DXR) was loaded into two kinds of thermo-responsive biodegradable star-shaped block copolymer (4arm PLGA-PEG) solutions with different PLGA block lengths under various conditions (drug-concentrations, polymer-concentrations and block compositions). All release profiles of DXR from star-block copolymer hydrogels showed sustained patterns. To assess this polymer as a sustained drug-delivery formulation, in vivo anti-tumor efficacy was examined by using tumor-bearing mice treated with DXR-loaded/ DXR-free hydrogels based on the result of the release study. After 1 month, the mice treated with DXR-loaded S11-C1 and DXR-loaded S9-C1 copolymer solutions had remarkably suppressed tumor-volume compared to that of the mice treated with DXR-free copolymer solution. And DXR-loaded S11 hydrogel showed more significant tumor inhibition due to the different hydrophobicity between S9 and S11 copolymers. In vitro release and in vivo anti-tumor activity studies performed for 1 month revealed the potential of this hydrogel as a sustained and long-term drug delivery carrier.
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Lee, S., Bae, Y., Kataoka, K. et al. In vitro Release and in vivo Anti-tumor Efficacy of Doxorubicin from Biodegradable Temperature-sensitive Star-shaped PLGA-PEG Block Copolymer Hydrogel. Polym J 40, 171–176 (2008). https://doi.org/10.1295/polymj.PJ2007179
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DOI: https://doi.org/10.1295/polymj.PJ2007179
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