Temperature- and pH-Controlled Hydrogelation of Poly(ethylene glycol)-Grafted Hyaluronic Acid by Inclusion Complexation with α-Cyclodextrin

Abstract

A series of poly(ethylene glycol) (PEG)-grafted hyaluronic acid (HA) was prepared by condensation reaction with hydrazide-terminated PEG using water soluble carbodiimide. PEG-grafted HA (PgH) solutions exhibited hydrogelation on adding α-cyclodextrin (α-CD). The solid-state 13C CP/MAS NMR spectroscopic and powder X-Ray diffraction measurements revealed the formation of inclusion complex between the PEG grafts and α-CD. The gel-melting temperature increased with increasing the degree of substitution of the PEG grafts and decreasing pH of aqueous medium. These results indicate that PgH hydrogels were constructed by inclusion complexation between the PEG grafts and α-CD, and the gel-melting temperature could be controlled by both the degree of substitution of the PEG grafts and pH.

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Nakama, T., Ooya, T. & Yui, N. Temperature- and pH-Controlled Hydrogelation of Poly(ethylene glycol)-Grafted Hyaluronic Acid by Inclusion Complexation with α-Cyclodextrin. Polym J 36, 338–344 (2004). https://doi.org/10.1295/polymj.36.338

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Keywords

  • Hyaluronic Acid
  • Inclusion Complex
  • α-Cyclodextrin
  • Poly(ethylene glycol)
  • Hydrogelation

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