Abstract
A series of poly(ethylene glycol) (PEG)-grafted hyaluronic acid (HA) was prepared by condensation reaction with hydrazide-terminated PEG using water soluble carbodiimide. PEG-grafted HA (PgH) solutions exhibited hydrogelation on adding α-cyclodextrin (α-CD). The solid-state 13C CP/MAS NMR spectroscopic and powder X-Ray diffraction measurements revealed the formation of inclusion complex between the PEG grafts and α-CD. The gel-melting temperature increased with increasing the degree of substitution of the PEG grafts and decreasing pH of aqueous medium. These results indicate that PgH hydrogels were constructed by inclusion complexation between the PEG grafts and α-CD, and the gel-melting temperature could be controlled by both the degree of substitution of the PEG grafts and pH.
Similar content being viewed by others
Article PDF
References
T. Nishikawa, K. Akiyoshi, and J. Sunamoto, J. Am. Chem. Soc., 118, 6110 (1996).
S. J. de Jong, B. van Eerdenbrugh, C. F. Van Nostrum, J. J. Kettenes-van den Bosch, and W. E. Hennink, J. Control. Release, 72, 47 (2001).
B. S. Lele and A. S. Hoffman, J. Control. Release, 69, 237 (2000).
J. Li, A. Harada, and M. Kamachi, Polym. J., 26, 1019 (1994).
T. Ooya and N. Yui, Crit. Rev. Ther. Drug Carrier Syst., 16, 289 (1999).
T. Ooya and N. Yui, Macromol. Chem. Phys., 199, 2311 (1998).
T. Ooya and N. Yui, J. Control. Release, 58, 251 (1999).
T. Ooya, M. Eguchi, and N. Yui, J. Am. Chem. Soc., 125, 13016 (2003).
J. Watanabe, T. Ooya, and N. Yui, Chem. Lett., 10, 1031 (1998).
J. Watanabe, T. Ooya, and N. Yui, J. Biomater. Sci., Polym. Ed., 10, 1275 (1999).
T. Ichi, J. Watanabe, T. Ooya, and N. Yui, Biomacromolecules, 2, 204 (2001).
K. M. Huh, T. Ooya, W. K. Lee, S. Sasaki, I. C. Kwon, S. Y. Jeong, and N. Yui, Macromolecules, 34, 8657 (2001).
H. S. Choi, K. Kontani, K. M. Huh, S. Sasaki, T. Ooya, and N. Yui, Macromol. Biosci., 2, 298 (2002).
K. Moriyama, T. Ooya, and N. Yui, J. Control. Release, 59, 77 (1999).
S. T. Lim, G. P. Martin, D. J. Berry, and M. B. Brown, J. Control. Release, 15, 281 (2000).
Y. Luo, M. R. Ziebell, and G. D. Prestwich, Biomacromolecules, 1, 208 (2000).
Y. Luo, R. Kirker, and G. D. Prestwich, J. Control. Release, 3, 169 (2000).
M. R. Kim and T. G. Park, J. Control. Release, 23, 69 (2002).
L. S. Liu, A. Y. Thompson, M. A. Heidaran, and J. W. Poster, Biomaterials, 20, 1097 (1999).
S. Ohya, Y. Nakayama, and T. Matsuda, Biomacromolecules, 2, 856 (2001).
S. N. Park, J. C. Park, H. O. Kim, M. J. Song, and H. Suh, Biomaterials, 23, 1205 (2002).
N. Yui, T. Okano, and Y. Sakurai, J. Control. Release, 22, 105 (1992).
N. Yui, J. Nihira, T. Okano, and Y. Sakurai, J. Control. Release, 25, 133 (1993).
T. Pouyani, G. S. Harbison, and G. D. Prestwich, J. Am. Chem. Soc., 116, 7515 (1994).
A. Harada, J. Li, and M. Kamachi, Macromolecules, 26, 5698 (1993).
M. J. Gidley and S. M. Bociek, J. Am. Chem. Soc., 110, 3820 (1988).
T. Nakama, T. Ooya, and N. Yui, Macromol. Rapid Commun., in press (2004).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Nakama, T., Ooya, T. & Yui, N. Temperature- and pH-Controlled Hydrogelation of Poly(ethylene glycol)-Grafted Hyaluronic Acid by Inclusion Complexation with α-Cyclodextrin. Polym J 36, 338–344 (2004). https://doi.org/10.1295/polymj.36.338
Published:
Issue Date:
DOI: https://doi.org/10.1295/polymj.36.338
Keywords
This article is cited by
-
Recent studies on modulating hyaluronic acid-based hydrogels for controlled drug delivery
Journal of Pharmaceutical Investigation (2022)
-
Polyrotaxanes for applications in life science and biotechnology
Applied Microbiology and Biotechnology (2011)
-
Self-assembled supramolecular hydrogels based on polymer–cyclodextrin inclusion complexes for drug delivery
NPG Asia Materials (2010)
-
Thermo-sensitive hydrogels formed from the photocrosslinkable polypseudorotaxanes consisting of β-cyclodextrin and Pluronic F68/PCL macromer
Journal of Polymer Research (2010)