Abstract
The preparation and characterization of polymers derived from hydroxyproline were investigated. Two new polymers of poly(trans-4-hydroxy-N-benzyloxycarbonyl-L-proline) [poly(N-Z-Hpr-OH)] and poly(trans-4-hydroxy-N-benzyloxycarbonyl-L-proline ester) [poly(N-Z-Hpr-OMe)], with easily removable pendant N-benzyloxycarbonyl group, were prepared. Weight-average molecular weight (Mw) of about 254000 and 33000 were obtained via esterification or transesterification, using stannous octoate as a catalyst, at 140°C under vacuum (20 mmHg) for 16 h. Removal of the N-benzyloxycarbonyl group by catalytic transfer hydrogenation yielded pseudopoly(trans-4-hydroxy-L-proline ester) [poly(Hpr-OMe·HCl)].
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Lee, RS., Yang, JM. & Huang, KH. Preparation and Characterization of Pseudopoly(trans-4-hydroxy-L-proline ester). Polym J 31, 569–573 (1999). https://doi.org/10.1295/polymj.31.569
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DOI: https://doi.org/10.1295/polymj.31.569