Abstract
Copolypeptides were synthesized by the multicomponent copolymerization of N-carboxy-α-amino acid anhydrides of Glu(OBzl), Phe, Leu, Cys(Bzl), Lys(Z), Orn(Z), Ala, or Gly. The copolymerization was proceeded by ideal random copolymerization. Multicomponent polypeptides obtained here were high-molecular-weight, mostly soluble in aprotic solvent, and formed films having high tensile strength and transparency.
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C. H. Li, “Hormonal Peptides,” Vol. 2, Academic Press, New York, N.Y., 1973, p 64.
M. Oya and R. Katakai, in “Shin Jikken Kagaku Koza, Vol. 19 (1), Polypeptides,” The Chemical Society of Japan. Ed., Maruzen Co., Tokyo, 1978, p 244.
M. Oya, K. Uno, and Y. Iwakura, in “Progress in Polymer Science Japan, Vol. 6: Preparation of Polypeptides and Oligopeptides from N-Carboxy-α-amino Acid anhydrides in Acetonitrile,” K. Uno and S. Onogi,, Ed., Kodansha, Tokyo, 1973, p 51.
E. Katchalski and M. Sela, “Advance in Protein Chemrstry VIII,” Academic Press, New York, N.Y., 1958, p 438.
M. Oya and Y. Iizuka, in “Aminosan Porima: Poriaminosan no Gousei,” T. Endo, Ed., CMC, Tokyo, 1988, p 32.
Y. Iwakura, K. Uno, and M. Oya, J. Polym. Sci., A, 6, 216 (1967).
E. Katchalski, J. Am. Chem. Soc., 82, 1630 (1960).
Y. Shalitin, Anal. Chem., 33, 1887 (1961).
A. Bax and D. G. Davis, J. Magn. Reson., 65, 355 (1985).
G. C. K. Robert and J. O. Jardetzky, Adv. Protein Chem., 24, 477 (1970).
C. C. McDonald and W. D. Phillips, J. Am. Chem. Soc., 91, 1513 (1969).
A. Bundi, Ch. Grathwohl, J. Hochmann, R. M. Keller, G. Wagner, and K. Wuethrich, J. Magn. Reson., 18, 191 (1975).
J. T. Yang and P. Doty, J. Am. Chem. Soc., 79, 761 (1967).
G. Holzworth and P. Doty, J. Am. Chem. Soc., 87, 218 (1965).
R. Towned, T. F. Kumosinski, S. N. Timosheff, and G. D. Fasman, Biochem. Biophys. Res. Commun., 23, 163 (1966).
M. Oya, K. Uno, and Y. Iwakura, J. Polym. Sci., 10, 613 (1972).
Y. Iizaka, M. Oya, T. Hayashi, and M. Iwatsuki, Kobunshi Ronbunshu, 48, 246 (1991).
M. Oya, M. Tomizawa, K. Uno, and Y. Iwakura, Bull. Chem. Sci. Jpn., 43, 3486 (1970).
M. Oya, T. Endo, and Y. Iizuka, Polym. J., 20, 557 (1988).
M. Oya and H. Kyotani, Polym. J., 18, 513 (1986).
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Iizuka, Y., Wakamatsu, K., Mitomo, H. et al. Synthesis and Properties of Multicomponent Synthetic Polypeptides. Polym J 25, 659–669 (1993). https://doi.org/10.1295/polymj.25.659
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DOI: https://doi.org/10.1295/polymj.25.659