Abstract
A water-soluble polymer having galactose pendant groups was prepared by the synthesis and radical polymerization of p-vinylbenzyl galactoside. Copolymerization of the galactoside with p-vinylphenyl acetate and subsequent [125I]labeling by a chloramine-T method afforded a radio-labeled galactose-containing polymer, and the body distribution of the polymer in mice was examined along with that of galactosylated bovine serum albumin (BSA). Both [125I]labeled galactose-containing polymer and [14C]labeled galactosylated BSA highly accumulated in the liver (>90%) soon after intravenous administration. The excretion of the synthetic vinyl polymer from the liver was very slow, and 92% and 63% of the administered radioactivity still remained in the liver 2 and 24 h after the injection, respectively, while only 18% of the radioactivity was recovered 2 h after the injection of [14C]labeled galactosylated BSA.
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Koyama, Y., Ishikawa, M., Ueda, A. et al. Body Distribution of Galactose-Containing Synthetic Polymer and Galactosylated Albumin. Polym J 25, 355–361 (1993). https://doi.org/10.1295/polymj.25.355
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DOI: https://doi.org/10.1295/polymj.25.355