Abstract
Synthesis and some properties of polymers having pendant amino sugars are described. Radical polymerization of the p-vinylphenyl glycoside of 3,4,6-tri-O-acetyl-D-glucosamine gave the corresponding polymer with ηinh 0.38—0.75 in high yield, which was soluble in DMAc, methanol, and pyridine. Deacetylation of the polymer by alkaline hydrolysis afforded a polymer having free glucosamine groups linked at the C-1 position. N-Acetylation of the original polymer followed by selective O-deacetylation converted the pendant groups to N-acetyl-glucosamine residues. The interaction of these polymers with wheat germ agglutinin and potato lectin was examined, and the N-acetylglucosamine-containing polymer was found to have a strong affinity for the lectins.
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Koyama, Y., Yoshida, A. & Kurita, K. Polymers Having Pendant Amino Sugar Groups: Synthesis and Bioactivity of Polymers Having Free Glucosamine and N-Acetylglucosamine. Polym J 18, 479–485 (1986). https://doi.org/10.1295/polymj.18.479
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DOI: https://doi.org/10.1295/polymj.18.479