Abstract
Thermodynamic quantities of dyes (proflavine, PF and 9-aminoacridine, 9AA) bound to the poly(I)·poly(C) duplex in the intercalation process have been evaluated from measurement of the heat of mixing. The free energy change for the duplex–PF system is smaller than that for the duplex–9AA system, indicating that the intercalation of PF into the poly(I)·poly(C) duplex is more stable than the intercalation of 9AA, as in the case of that in the poly(A)·poly(U) duplex–dye system reported previously. This conclusion was drawn from the heat of interaction between PF and poly(I)·poly(C) duplex being larger than that between 9AA and poly(I)·poly(C) duplex. In addition, the enthalpy change of the poly(I)·poly(C) duplex–dye system is smaller than that of poly(A)·poly(U) duplex–dye one, suggesting that the conformational change of the poly(I)·poly(C) duplex in the intercalation process is considerably larger than that of the poly(A)·poly(U) duplex.
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Kano, K., Baba, Y., Kagemoto, A. et al. The Thermodynamic Characterization of Poly(I)·Poly(C) Duplex–Aminoacridine Dye System. Polym J 15, 657–661 (1983). https://doi.org/10.1295/polymj.15.657
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DOI: https://doi.org/10.1295/polymj.15.657