Abstract
A-B-A tri-block copolymers consisting of DL-isomers of poly(γ-methyl gluta-mate) as the A component and polybutadiene as the B component were prepared. The synthesis was carried out by polymerizing an equimolar mixture of γ-methyl D-glutamate and γ-methyl L-glutamate NCA with the amine groups capped at both ends of the polybutadiene block or the initiator. By infrared spectroscopy, it was found that the copolypeptide chain block exists not only in an α-helical conformation but also in a random coil conformation. On the basis of contact angle measurements, replication electron micrographs, and attenuated total reflection-infrared spectra, it was concluded that the surface of the present block copolymer membranes has a microheterophase structure consisting of the copolypeptide and hydrophobic domains, and also has a grainy surface structure with a grain size of 300—500 Å. Furthermore, the adsorption of plasma proteins onto these block copolymer membranes was investigated.
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K. Kugo, T. Hayashi, and A. Nakajima, Polym. J., 14, 391 (1982).
K. Kugo, T. Hayashi, and A. Nakajima, Polym. J., 14, 401 (1982).
E. Klein, P. D. May, J. K. Smith, and N. Leger, Biopolymers, 10, 647 (1971).
E. C. Martin, P. D. May, and W. A. McMahon, J. Biomed. Mater. Res., 5, 53 (1971).
J. M. Anderson, D. F. Gibbons, R. L. Martin, A. Hiltner, and R. Woods, J. Biomed. Mater. Res. Symp., 5, 197 (1974).
D. J. Lyman, K. Knutson, B. McNeill, and K. Shibatani, Trans. Am. Soc. Artif. Int. Organs, 21, 49 (1975).
E. Nyilas, W. A. Morton, D. M. Lederman, T.-H. Chiu, and R. D. Cumming, Trans. Am. Soc. Artif. Int. Organs, 21, 55 (1975).
T. Okano, S. Nishiyama, I. Shinohara, T. Akaike, and Y. Sakurai, Polym. J., 10, 223 (1978).
T. Okano, S. Nishiyama, I. Shinohara, T. Akaike, Y. Sakurai, K. Kataoka, and T. Tsuruta, J. Biomed. Mater. Res., 15, 393 (1981).
P. N. Sawyer, C. Burrowes, J. Ogoniak, A. O. Smith, and S. A. Wesolowski, Trans. Am. Soc. Artif. Int. Organs, 10, 316 (1964).
S. A. Barenberg, J. S. Schultz, J. M. Anderson, and P. H. Geil, Trans. Am. Soc. Artif. Int. Organs, 25, 159 (1979).
S. A. Barenberg, J. M. Anderson, and K. A. Mauritz, J. Biomed. Mater. Res., 15, 231 (1981).
C. S. Paik Sung, C. B. Hu, E. W. Merrill, and E. W. Salzman, J. Biomed. Mater. Res., 12, 791 (1978).
C. S. Paik Sung and C. B. Hu, J. Biomed. Mater. Res., 13, 45 (1979).
C. S. Paik Sung and C. B. Hu, J. Biomed. Mater. Res., 13, 161 (1979).
V. Sa Da Costa, D. Brier-Russell, E. W. Salzman, and E. W. Merrill, J. Colloid Interface Sci., 80,
V. Sa Da Costa, D. Brier-Russell, G. Turdel III, D. F. Waugh, E. W. Salzman, and E. W. Merrill, J. Colloid Interface Sci., 76, 594 (1980).
C. S. Paik Sung and C. B. Hu, J. Biomed. Mater. Res., 13, 161 (1979).
E. Nyilas, W. A. Morton, R. D. Cumming, D. M. Lederman, and T-H. Chiu, J. Biomed. Mater. Res. Symp., 8, 51 (1977).
A. Baszkin and D. J. Lyman, J. Biomed. Mater. Res., 14, 393. (1980).
K. Furusawa, Y. Shimura, K. Otobe, K. Atsumi, and K. Tsuda, Kobunshi Ronbunshu, 34, 309 (1977).
Y. Masuda, T. Miyazawa, and M. Goodman, Biopolymers, 8, 515 (1969).
A. Nakajima, T. Hayashi, K. Itoh, and T. Fujiwara, Polym. J., 4, 10 (1973).
T. Hayashi, K. Kugo, and A. Nakajima, Rep. Prog. Polym. Phys., Jpn., 21, 581 (1978).
A. Nakajima, T. Hayashi, K. Kugo, and K. Shinoda, Macromolecules, 12, 840 (1979).
E. R. Blout and R. H. Karlson, J. Am. Chem. Soc., 78, 941 (1956).
S. Tanaka and A. Nakajima, Bull. Inst. Chem. Res. Kyoto Univ., 54, 229 (1976).
P. Doty, J. Am. Chem. Soc., 79, 3961 (1957).
L. Wilhelmy, Ann. Physik Chem., 119, 177 (1863).
N. K. Adam and G. Jessop, J. Chem. Soc., 127, 1863 (1925).
K. Kato, Polym. Lett., 4, 35 (1966).
K. Kato, Polym. Eng. Sci., 7, 38 (1967).
K. Kato, Polymer, 9, 225 (1968).
K. Kato, Polymer, 9, 419 (1968).
J. F. Foster, M. Sogami, H. A. Petersen, and W. J. Leonard, Jr., J. Biol. Chem., 240, 2495 (1965).
V. R. Zurawski, Jr., W. J. Kohr, and J. F. Foster, Biochemistry, 14, 5579 (1975).
E. Mihalyi, Biochemistry, 7, 208 (1968).
T. Hayashi, K. Kugo, and A. Nakajima, Rep. Prog. Polym. Phys. Jpn., 25, 687 (1982).
T. Miyazawa and E. R. Blout, J. Am. Chem. Soc., 83, 712 (1961).
T. Miyazawa, Y. Masuda, and K. Fukushima, J. Polym. Sci., 62, S62 (1962).
S. L. Hsu, W. H. Moore, and S. Krimm, J. Appl. Phys., 46, 4185 (1975).
A. Nakajima, K. Kugo, and T. Hayashi, Macromolecules, 12, 844 (1979).
H. W. Fox and W. A. Zisman, J. Colloid Sci., 5, 514 (1950).
W. A. Zisman, “Contact Angle, Wettability and Adhesion,” Adv. Chem. Ser., No. 43 (1964).
R. E. Baier and W. A. Zisman, Macromolecules, 3, 70 (1970).
R. E. Baier and W. A. Zisman, Macromolecules, 3, 462 (1970).
A. H. Ellison and W. A. Zisman, J. Phys. Chem., 58, 503 (1954).
G. I. Loeb and R. E. Baier, J. Colloid Interface Sci., 27, 38 (1968).
L.-H. Lee, J. Polym. Sci., A-2, 5, 1103 (1967).
E. Vanzo, J. Polym. Sci., A-1, 4, 1727 (1966).
E. Vanzo, J. Polym. Sci., A-1, 6, 1661 (1968).
E. Vanzo, J. Polym. Sci., C, 26, 161 (1969).
J. L. Brash and S. Uniyal, J. Polym. Sci., Polym. Symp., 66, 377 (1979).
H. R. Thomas and J. J. O’Malley, Macromolecules, 12, 323 (1979).
N. J. Harrick, “Internal Reflection Spectroscopy,” Wiley, New York, N.Y., 1967, p 30.
A. Elliott and E. M. Bradbury, J. Mol. Biol., 5, 574 (1962).
A. Elliott and E. M. Bradbury, Polymer, 4, 47 (1963).
M. Beer, G. B. B. M. Sutherland, K. N. Tanner, and D. L. Wood, Proc R. Soc. London, Ser. A, 249, 147 (1959).
B. W. Morrissey and R. R. Stronberg, J. Colloid Interface Sci., 46, 152 (1974).
J. L. Oncley, G. Scatchard, and A. Brown, J. Phys. Colloid Chem., 51, 134 (1947).
J. L. Brash and D. J. Lyman, J. Biomed. Mater. Res., 3, 175 (1969).
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Kugo, K., Murashima, M., Hayashi, T. et al. Structure and Properties of Membrane Surfaces of A-B-A Tri-Block Copolymers Consisting of Poly(γ-methyl D,L-glutamate) as the A Component and Polybutadiene as the B Component. Polym J 15, 267–277 (1983). https://doi.org/10.1295/polymj.15.267
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DOI: https://doi.org/10.1295/polymj.15.267