Abstract
Conformation-directing interactions between poly(L- or poly(D-glutamic acid)) (PLG or PDG) and poly-L-lysine (PLL) in aqueous media were investigated as functions of pH by using the optical rotatory dispersion and circular dichroism spectroscopies. The results indicate that at pH <4 PLL molecules surround the core of the right-handed α-helix of PLG, and at pH about 7, the polyelectrolyte complex formed may be in a scramble-salt form, whereas at pH >8, complexes of PLG—PLL are in a form close to β-structure. On the other hand, with PDG—PLL systems, in the low pH region, the left-handed α-helical structure of PDG is markedly disrupted by the presence of PLL, and in the high pH region, the complexes may be in a form of a scramble-salt aggregate composed of β-structures.
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Nakajima, A., Shinoda, K., Hayashi, T. et al. Interactions between Oppositely Charged Polypeptides. Polym J 7, 550–557 (1975). https://doi.org/10.1295/polymj.7.550
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DOI: https://doi.org/10.1295/polymj.7.550