Solution Properties of Synthetic Polypeptides. X. Transition Parameters for Poly(γ-benzyl-L-glutamate)

Abstract

Helix-initiation parameter σ and enthalpy change ΔH for helix–coil transition of poly(γ-benzyl-L-glutamate) in mixtures of dichloroacetic acid and ethylene dichloride were determined at fixed solvent conditions from the dependence of helical content of the dissolved polypeptide on its molecular weight. The values of \\sqrt{σ} obtained were substantially independent of solvent composition and temperature over the range where the substantial portion of the transition occurred, yielding (0.95±0.13)×10−2 on the average. This value stood in close agreement with that evaluated from calorimetric measurements by Ackermann and Neumann. On the other hand, ΔH depended slightly on solvent composition and had values between those of Ackermann and Neumann and of Karasz and O’Reilly.

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Norisuye, T., Matsuoka, M., Teramoto, A. et al. Solution Properties of Synthetic Polypeptides. X. Transition Parameters for Poly(γ-benzyl-L-glutamate). Polym J 1, 691–699 (1970). https://doi.org/10.1295/polymj.1.691

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Keywords

  • Helix–Coil Transition
  • Dilute Polymer Solution
  • Polypeptide
  • Helical Content
  • Helix-Initiation Parameter
  • Transition Enthalpy

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