Table 2 A dichotomous EXO106 score is predictive of initial biopsy results

From: A molecular signature of PCA3 and ERG exosomal RNA from non-DRE urine is predictive of initial prostate biopsy result

Any cancer, intended use, low volume
  Biopsy result       
  Biopsy negative Biopsy postitive Total Performance s.e. 95% CI
Exo106 cut point 57 22 79 NPV % 72.15 5.04 62.27 82.04
Exo106 >cut point 49 67 116 PPV % 57.76 4.59 48.77 66.75
Total 106 89 195      
  Specificity % Sensitivity %       
Performance 53.77 75.28   NLR 0.46    
s.e. 4.84 4.57   PLR 1.63    
95% CI 44.28 66.32       
  63.27 84.24       
High-grade cancer, intended use, low volume
  Biopsy result       
  Biopsy negative or GL=6 GL7 Total Performance s.e. 95% CI
Exo106cut point 77 2 79 NPV % 97.47 1.77 94.00 100.00
Exo106>cut point 76 40 116 PPV % 34.48 4.41 25.83 43.13
Total 153 42 195      
  Specificity % Sensitivity %       
Performance 50.33 95.24   NLR 0.09    
s.e. 4.04 3.29   PLR 1.92    
95% CI 42.40 88.80       
  58.25 100.00       
  1. Abbreviations: CI, confidence interval; NLR, negative likelihood ratio; NPV, negative predictive value; PLR, positive likelihood ratio; PPV, positive predictive value.