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Clinical Research

Prostate cancer susceptibility genes on 8p21–23 in a Dutch population

Prostate Cancer and Prostatic Diseases volume 16, pages 248–253 (2013)Cite this article

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Abstract

Background:

Prostate cancer is the most commonly diagnosed cancer in men in Europe and the United States. Numerous studies have indicated genetics to have a major role in the aetiology of this disease; as much as 42% of the risk may be explained by heritable factors. Genome-wide association studies have detected an association between prostate cancer and chromosome 8p21–23. In this study, we analysed eight microsatellite (MS) markers in that region in order to confirm previous results and narrow down the location of candidate prostate cancer genes.

Methods:

292 cases and 278 controls were selected from the Netherlands Cohort Study (NLCS). The following MSs were used in the analyses: D8S136, D8S1734, D8S1742, D8S261, D8S262, D8S351, D8S511 and D8S520. Associations were evaluated using a χ2 test and logistic regression. We checked for any effects on the association by tumour stage.

Results:

Associations that were found confirmed previous research that pointed to the 8p21–23 region. Two MSs: D8S136 (odds ratio (OR), 0.69; P=4.00 × 10−28), and D8S520 (OR, 0.80; P=3.37 × 10−11), were consistently and strongly related with prostate cancer. Genotype analysis showed an additive effect for D8S136 (P-trend=6.22 × 10−03) and D8S520 (P-trend=2.62 × 10−22), suggesting an increased risk for people with a short number of repeats on both alleles at those markers.

Conclusions:

This study provides strong evidence that the 8p21–23 region is likely to harbour prostate cancer genes.

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Acknowledgements

This study was established with financial support from the Dutch Cancer Society and the US Department of Defense.

Author information

Author notes

  1. M P Zeegers and D Nekeman: Both authors contributed equally to this work.

Authors and Affiliations

  1. Department of Public Health, Unit of Urologic and Genetic Epidemiology, Epidemiology and Biostatistics, School of Health and Population Sciences, University of Birmingham, Birmingham, UK

    M P Zeegers, D Nekeman & H S Khan

  2. Department of Genetics and Cell Biology, Section of Complex Genetics, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands

    M P Zeegers

  3. GROW—School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands

    D Nekeman, B A C van Dijk, P A van den Brandt & L J Schouten

  4. TNO Quality of Life, Business Unit Prevention and Care, Leiden, The Netherlands

    R A Goldbohm

  5. Department of Urology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands

    J Schalken

  6. Human Genetics Program, School of Medicine, New York University, New York, NY, USA

    S Shajahan, A Pearlman, C Oddoux & H Ostrer

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  1. M P Zeegers
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Correspondence to D Nekeman.

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Appendix 1

Appendix 1

Table a1 Odds ratios of prostate cancer by repeat size (long versus short) of eight microsatellite markers on chromosome 8p21–23
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Zeegers, M., Nekeman, D., Khan, H. et al. Prostate cancer susceptibility genes on 8p21–23 in a Dutch population. Prostate Cancer Prostatic Dis 16, 248–253 (2013). https://doi.org/10.1038/pcan.2013.9

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