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  • Original Article
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Clinical Research

Impact of statin use on biochemical recurrence in patients treated with radical prostatectomy

Prostate Cancer and Prostatic Diseases volume 16, pages 367–371 (2013)Cite this article

Subjects

Abstract

Background:

The impact of statin use on biochemical recurrence (BCR) in patients treated with radical prostatectomy (RP) remains controversial.

Methods:

We retrospectively evaluated 6842 patients who underwent RP for clinically localized prostate cancer (PC) between 2000 and 2011. Uni- and multivariable cox regression models addressed the association of statin use with BCR.

Results:

Overall, 2275 (33.3%) patients used statins. Statin users were older and had a higher rate of positive surgical margins than patients not using statins (P-values ⩽0.05). Within a median follow-up of 25 months (interquartile range: 8–42 months), 778 (11.4%) patients experienced BCR. Actuarial estimate 5-years BCR-free survival was 82%±1 for patients without statin use and 84±1% for patients using statins (P=0.05); statin use was not associated with BCR (hazard ratio: 0.88, 95% confidence interval: 0.76–1.03, P=0.10) after adjusting for the effects of standard clinicopathologic features.

Conclusions:

In PC patients undergoing RP, statin use was not independently associated with lower risk of BCR.

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Authors and Affiliations

  1. Department of Urology, Weill Cornell Medical College, New York Presbyterian Hospital, New York, NY, USA

    M Rieken, L A Kluth, E Xylinas, T Faison, J J Crivelli, D S Scherr, A K Tewari & S F Shariat

  2. Department of Urology, University Hospital Basel, Basel, Switzerland

    M Rieken & A Bachmann

  3. Department of Urology, University Medical-Center Hamburg-Eppendorf, Hamburg, Germany

    L A Kluth

  4. Department of Urology, Cochin Hospital, Assistance Publique-Hopitaux de Paris, Paris Descartes University, Paris, France

    E Xylinas

  5. Department of Urology, Medical University of Vienna, Vienna, Austria

    C Seitz, H Fajkovic & S F Shariat

  6. Department of Urology, University of Montreal, Montreal, Quebec, Canada

    P I Karakiewicz

  7. Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Y Lotan

  8. Department of Urology, Urological Research Institute, San Raffaele Scientific Institute, Milan, Italy

    A Briganti

  9. Prostate Cancer Center, Hospital Barmherzige Schwestern Linz, Linz, Austria

    W Loidl

  10. Division of Endocrinology and Metabolism, Department of Internal Medicine III, Unit of Gender Medicine, Medical University of Vienna, Vienna, Austria

    A Kautzky-Willer

  11. Department of Urology, Medical University of Graz, Graz, Austria

    K Pummer

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  1. M Rieken
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Corresponding author

Correspondence to S F Shariat.

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Competing interests

M. Rieken received Grant Support from Swiss National Science Foundation. A. Bachmann is the company consult for American Medical Systems, Caris Life Sciences, Olympus, Orion Pharma, Schering. S.F. Shariat is the member of Advisory Board for Ferring Pharmaceuticals. The remaining authors declare no conflict of interest.

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Rieken, M., Kluth, L., Xylinas, E. et al. Impact of statin use on biochemical recurrence in patients treated with radical prostatectomy. Prostate Cancer Prostatic Dis 16, 367–371 (2013). https://doi.org/10.1038/pcan.2013.31

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  • DOI: https://doi.org/10.1038/pcan.2013.31

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