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Basic Research

Variants in the HEPSIN gene are associated with susceptibility to prostate cancer

Prostate Cancer and Prostatic Diseases volume 15, pages 353–358 (2012)Cite this article

Subjects

Abstract

Background:

HEPSIN (HPN) gene is one of the most consistently overexpressed genes in patients with prostate cancer; furthermore, there is some evidence supporting an association between HPN gene variants and the risk of developing prostate cancer. In this study, sequence variants in the HPN gene were investigated to determine whether they were associated with prostate cancer risk in a Korean study cohort.

Methods:

We evaluated the association of 17 single-nucleotide polymorphisms (SNPs) in the HPN gene with prostate cancer risk and clinical characteristics (Gleason score and tumor stage) in Korean men (240 case subjects and 223 control subjects) using unconditional logistic regression.

Results:

The statistical analysis suggested that three SNPs (rs45512696, rs2305745, rs2305747) were significantly associated with the risk of prostate cancer (odds ratio (OR)=2.22, P=0.04; OR=0.73, P=0.03; OR=0.76, P=0.05, respectively).

Conclusions:

The results of this study suggest that, in Korean men, some polymorphisms in the HPN gene might be associated with the risk of developing prostate cancer.

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Acknowledgements

This work was supported by a grant from the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (A085138).

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Author notes

  1. H J Kim and J H Han: These authors contributed equally to this work.

Authors and Affiliations

  1. Advanced Urogenital Disease Research Center, Chung-Ang University College of Medicine, Seoul, Korea

    H J Kim, I H Chang, W Kim & S C Myung

  2. Research Institute for Translational System Biomics, Chung-Ang University College of Medicine, Seoul, Korea

    H J Kim, I H Chang, W Kim & S C Myung

  3. Department of Urology, Korea Electric Power Company Medical Foundation Hanil General Hospital, Seoul, Korea

    J H Han

  4. Department of Urology, Chung-Ang University College of Medicine, Seoul, Korea

    I H Chang & S C Myung

  5. Department of Microbiology, Chung-Ang University College of Medicine, Seoul, Korea

    W Kim

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  1. H J Kim
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Corresponding author

Correspondence to S C Myung.

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The authors declare no conflict of interest.

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Supplementary Information accompanies the paper on the Prostate Cancer and Prostatic Diseases website

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Kim, H., Han, J., Chang, I. et al. Variants in the HEPSIN gene are associated with susceptibility to prostate cancer. Prostate Cancer Prostatic Dis 15, 353–358 (2012). https://doi.org/10.1038/pcan.2012.17

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