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Clinical Research

Relationship of statins to clinical presentation and biochemical outcomes after radical prostatectomy in Korean patients

Prostate Cancer and Prostatic Diseases volume 14, pages 63–68 (2011)Cite this article

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Abstract

The aim of this study was to determine whether or not statins influence biochemical recurrence (BCR) in Korean patients undergoing surgical treatment for prostate cancer. We reviewed data from 687 men who underwent radical retropubic prostatectomy and who did not receive neoadjuvant treatment. Of these patients, 87 reported the use of preoperative statins at surgery. BCR-free survival was determined after exclusion of 78 patients with lymph node metastases and/or who received immediate adjuvant treatment. Patients on statin therapy were more likely to have a co-morbid disease (P<0.05). Mean PSA (9.6 vs 13.6 ng ml−1, P=0.002) and PSA density (0.27 vs 0.38 ng ml−1 ml−1, P<0.001) were significantly lower in patients on statins. However, in the multivariable linear regression model, statin use was not associated with a decrease in PSA. Overall BCR for the entire cohort was not significantly different between the statin and nonstatin groups. On multivariate analysis, positive surgical margin and seminal vesicle invasion were independent risk factors for BCR-free survival, whereas other variables, including statin use, were not significant in predicting the risk of BCR. Patients with positive surgical margin and seminal vesicle invasion had a 2.1- (odds ratio, 2.15; 95% confidence interval, 1.29–3.57; P=0.003) and 2.2-fold risk (odds ratio, 2.21; 95% confidence interval, 1.25–3.89; P=0.006) of BCR. Preoperative statin use is not associated with reduced BCR following radical prostatectomy.

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References

  1. Baigent C, Keech A, Kearney PM, Blackwell L, Buck G, Pollicino C et al. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90 056 participants in 14 randomised trials of statins. Lancet 2005; 366: 1267–1278.

    Article  CAS  Google Scholar 

  2. Blais L, Desgagne A, LeLorier J . 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors and the risk of cancer: a nested case-control study. Arch Intern Med 2000; 160: 2363–2368.

    Article  CAS  PubMed  Google Scholar 

  3. Poynter JN, Gruber SB, Higgins PD, Almog R, Bonner JD, Rennert HS et al. Statins and the risk of colorectal cancer. N Engl J Med 2005; 352: 2184–2192.

    Article  CAS  PubMed  Google Scholar 

  4. Chan KK, Oza AM, Siu LL . The statins as anticancer agents. Clin Cancer Res 2003; 9: 10–19.

    CAS  PubMed  Google Scholar 

  5. Demierre MF, Higgins PD, Gruber SB, Hawk E, Lippman SM . Statins and cancer prevention. Nat Rev Cancer 2005; 5: 930–942.

    Article  CAS  PubMed  Google Scholar 

  6. Cyrus-David MS, Weinberg A, Thompson T, Kadmon D . The effect of statins on serum prostate specific antigen levels in a cohort of airline pilots: a preliminary report. J Urol 2005; 173: 1923–1925.

    Article  CAS  PubMed  Google Scholar 

  7. Hamilton RJ, Goldberg KC, Platz EA, Freedland SJ . The influence of statin medications on prostate-specific antigen levels. J Natl Cancer Inst 2008; 100: 1511–1518.

    Article  CAS  PubMed  Google Scholar 

  8. Platz EA, Leitzmann MF, Visvanathan K, Rimm EB, Stampfer MJ, Willett WC et al. Statin drugs and risk of advanced prostate cancer. J Natl Cancer Inst 2006; 98: 1819–1825.

    Article  CAS  PubMed  Google Scholar 

  9. Jacobs EJ, Rodriguez C, Bain EB, Wang Y, Thun MJ, Calle EE . Cholesterol-lowering drugs and advanced prostate cancer incidence in a large US cohort. Cancer Epidemiol Biomarkers Prev 2007; 16: 2213–2217.

    Article  CAS  PubMed  Google Scholar 

  10. Flick ED, Habel LA, Chan KA, Van Den Eeden SK, Quinn VP, Haque R et al. Statin use and risk of prostate cancer in the California Men's Health Study cohort. Cancer Epidemiol Biomarkers Prev 2007; 16: 2218–2225.

    Article  CAS  PubMed  Google Scholar 

  11. Murtola TJ, Tammela TL, Lahtela J, Auvinen A . Cholesterol-lowering drugs and prostate cancer risk: a population-based case-control study. Cancer Epidemiol Biomarkers Prev 2007; 16: 2226–2232.

    Article  CAS  PubMed  Google Scholar 

  12. D’Amico AV, Whittington R, Malkowicz SB, Schultz D, Blank K, Broderick GA et al. Biochemical outcome after radical prostatectomy, external beam radiation therapy, or interstitial radiation therapy for clinically localized prostate cancer. JAMA 1998; 280: 969–974.

    Article  PubMed  Google Scholar 

  13. Chen ME, Johnston D, Reyes AO, Soto CP, Babaian RJ, Troncoso P . A streamlined three-dimensional volume estimation method accurately classifies prostate tumors by volume. Am J Surg Pathol 2003; 27: 1291–1301.

    Article  PubMed  Google Scholar 

  14. Werny DM, Saraiya M, Gregg EW . Prostate-specific antigen values in diabetic and nondiabetic US men, 2001–2002. Am J Epidemiol 2006; 164: 978–983.

    Article  PubMed  Google Scholar 

  15. Cookson MS, Aus G, Burnett AL, Canby-Hagino ED, D’Amico AV, Dmochowski RR . Variation in the definition of biochemical recurrence in patients treated for localized prostate cancer: the American Urological Association Prostate Guidelines for Localized Prostate Cancer Update Panel report and recommendations for a standard in the reporting of surgical outcomes. J Urol 2007; 177: 540–545.

    Article  CAS  PubMed  Google Scholar 

  16. Jakobisiak M, Golab J . Potential antitumor effects of statins (Review). Int J Oncol 2003; 23: 1055–1069.

    CAS  PubMed  Google Scholar 

  17. Graaf MR, Beiderbeck AB, Egberts AC, Richel DJ, Guchelaar HJ . The risk of cancer in users of statins. J Clin Oncol 2004; 22: 2388–2394.

    Article  CAS  PubMed  Google Scholar 

  18. Shannon J, Tewoderos S, Garzotto M, Beer TM, Derenick R, Palma A et al. Statins and prostate cancer risk: a case-control study. Am J Epidemiol 2005; 162: 318–325.

    Article  PubMed  Google Scholar 

  19. Friis S, Poulsen AH, Johnsen SP, McLaughlin JK, Fryzek JP, Dalton SO et al. Cancer risk among statin users: a population-based cohort study. Int J Cancer 2005; 114: 643–647.

    Article  CAS  PubMed  Google Scholar 

  20. Agalliu I, Salinas CA, Hansten PD, Ostrander EA, Stanford JL . Statin use and risk of prostate cancer: results from a population-based epidemiologic study. Am J Epidemiol 2008; 168: 250–260.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Ford I, Murray H, Packard CJ, Shepherd J, Macfarlane PW, Cobbe SM et al. Long-term follow-up of the West of Scotland Coronary Prevention Study. N Engl J Med 2007; 357: 1477–1486.

    Article  CAS  PubMed  Google Scholar 

  22. Banez LL, Klink JC, Jayachandran J, Lark AL, Gerber L, Hamilton RJ et al. Association between statins and prostate tumor inflammatory infiltrate in men undergoing radical prostatectomy. Cancer Epidemiol Biomarkers Prev 2010; 19: 722–728.

    Article  CAS  PubMed  Google Scholar 

  23. Soto DE, Daignault S, Sandler HM, Ray ME . No effect of statins on biochemical outcomes after radiotherapy for localized prostate cancer. Urology 2009; 73: 158–162.

    Article  PubMed  Google Scholar 

  24. Moyad MA, Merrick GS, Butler WM, Wallner KE, Galbreath RW, Kurko B et al. Statins, especially atorvastatin, may favorably influence clinical presentation and biochemical progression-free survival after brachytherapy for clinically localized prostate cancer. Urology 2005; 66: 1150–1154.

    Article  PubMed  Google Scholar 

  25. Gutt R, Tonlaar N, Kunnavakkam R, Karrison T, Weichselbaum RR, Liauw SL . Statin use and risk of prostate cancer recurrence in men treated with radiation therapy. J Clin Oncol 2010; 28: 2653–2659.

    Article  CAS  PubMed  Google Scholar 

  26. Loeb S, Kan D, Helfand BT, Nadler RB, Catalona WJ . Is statin use associated with prostate cancer aggressiveness? BJU Int 2010; 105: 1222–1225.

    Article  CAS  PubMed  Google Scholar 

  27. Krane LS, Kaul SA, Stricker HJ, Peabody JO, Menon M, Agarwal PK . Men presenting for radical prostatectomy on preoperative statin therapy have reduced serum prostate specific antigen. J Urol 2010; 183: 118–124.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Urology, Seoul National University Hospital, Seoul, Korea

    J H Ku, C W Jeong, Y H Park, M C Cho, C Kwak & H H Kim

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  1. J H Ku
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Correspondence to H H Kim.

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Ku, J., Jeong, C., Park, Y. et al. Relationship of statins to clinical presentation and biochemical outcomes after radical prostatectomy in Korean patients. Prostate Cancer Prostatic Dis 14, 63–68 (2011). https://doi.org/10.1038/pcan.2010.39

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