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Genetic variation in adiponectin (ADIPOQ) and the type 1 receptor (ADIPOR1), obesity and prostate cancer in African Americans

Prostate Cancer and Prostatic Diseases volume 13, pages 362–368 (2010)Cite this article

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Abstract

Adiponectin is a protein derived from adipose tissue suspected to have an important role in prostate carcinogenesis. Variants in the adiponectin gene (ADIPOQ) and its type 1 receptor (ADIPOR1) have been recently linked to risk of both breast and colorectal cancer. Therefore, we set out to examine the relationship between polymorphisms in these genes, obesity and prostate cancer in study of African-American men. Ten single-nucleotide polymorphisms (SNPs) in ADIPOQ and ADIPOR1 were genotyped in DNA samples from 131 African-American prostate cancer cases and 344 controls participating in the Flint Men's Health Study. Logistic regression was then used to estimate their association with prostate cancer and obesity. While no significant associations were detected between any of the tested SNPs and prostate cancer, the rs1501299 SNP in ADIPOQ was significantly associated with body mass (P=0.03). Genetic variation in ADIPOQ and ADIPOR1 did not predict risk of prostate cancer in this study of African-American men. However, the rs1501299 SNP in ADIPOQ was associated with obesity. Further investigation is warranted to determine if racial differences exist in the influence of the adiponectin pathway on prostate cancer risk.

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Acknowledgements

This study was supported by NIH grants: UM Prostate S.P.O.R.E. P50 CA69568, R01 CA79596 and K07 CA127214.

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Authors and Affiliations

  1. Department of Population Studies and Prevention, Department of Internal Medicine, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA

    J L Beebe-Dimmer

  2. Departments of Internal Medicine and Urology, University of Michigan Medical School, Ann Arbor, MI, USA

    K A Zuhlke & A M Ray

  3. Departments of Genetics and Biostatistics, University of North Carolina, Chapel Hill, NC, USA

    E M Lange

  4. Departments of Internal Medicine and Urology, University of Michigan Medical School, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA

    K A Cooney

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  1. J L Beebe-Dimmer
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Correspondence to J L Beebe-Dimmer.

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Beebe-Dimmer, J., Zuhlke, K., Ray, A. et al. Genetic variation in adiponectin (ADIPOQ) and the type 1 receptor (ADIPOR1), obesity and prostate cancer in African Americans. Prostate Cancer Prostatic Dis 13, 362–368 (2010). https://doi.org/10.1038/pcan.2010.27

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