Figure 1 | Oncogenesis

Figure 1

From: Understanding cachexia as a cancer metabolism syndrome

Figure 1

The simplified scheme represents the major organs commonly affected during cachexia progression and how they fuel tumor growth. In brief, tumor tissue and the co-opted immune system secrete specific factors, thus promoting skeletal muscle wasting and lipolysis. Pro-inflammatory cytokines contribute to develop anorexia and insulin resistance, ultimately worsening skeletal muscle wasting. Gastrointestinal tract tumors and bone metastasis can promote further cachexia by causing endotoxemia and transforming growth factor beta release, respectively. (Adapted from Servier Medical Art, www.servier.com).

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