Figure 6 | Oncogene

Figure 6

From: Hepatic cyclooxygenase-2 overexpression induced spontaneous hepatocellular carcinoma formation in mice

Figure 6

COX-2-induced hypermethylated genes (ADCY5, Ltbp1 and Prkcz) are novel tumor suppressors inactivated by DNA methylation in human HCC. (a) The mRNA expression level of ADCY5, Ltbp1 and Prkcz in 16 normal livers (NL), 30 pairs of HCC (T) and adjacent non-HCC (NT) liver tissues. Data are represented by mean±s.d. P-values were obtained by Mann–Whitney U-test or Wilcoxon matched-pairs test. (*P<0.05, **P<0.01, ***P<0.001). (b) The mRNA expression level of ADCY5, Ltbp1 and Prkcz in 371 primary HCC (T) and 50 adjacent non-HCC (NT) liver tissue from TCGA LIHC (liver HCC) data set. Data are represented by mean±s.d. P-values were obtained by Mann–Whitney U-test. (*P<0.05, **P<0.01, ***P<0.001). (c) The Spearson correlation between mRNA expression level and methylation level of ADCY5, Ltbp1 and Prkcz in 371 primary HCC samples from TCGA data. The gene methylation levels were determined as the average beta-values of different probes, which are mapped to CpG island in their promoter regions on genes.

Back to article page