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XRN2 promotes EMT and metastasis through regulating maturation of miR-10a

Oncogene volume 36, pages 3925–3933 (2017)Cite this article

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Abstract

MicroRNAs (miRNAs) have been proposed as critical regulatory molecules in the epithelial–mesenchymal transition (EMT) program. However, the roles of mature miRNA biogenesis during EMT process needs to be defined. Here we determined that increased expression of XRN2 induced EMT and promoted metastasis in vitro and in vivo. Furthermore, we uncovered that XRN2 functions as pro-metastatic gene, which accelerates miR-10a maturation by binding pre-miR-10a in a DICER-independent manner. These findings suggest that XRN2 is a novel regulator of EMT that contributes to the metastatic processes in lung cancer through a novel miRNA regulatory mechanism.

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Acknowledgements

This work has been support by National Natural Science Foundation of China (no. 81372514, 81472420, 81572256 and 31401125), National Key Research and Development program (2016YFA0501800 and 2016YFC0902700), the Fundamental Research Funds for the Central Universities and 1000 talent Plan of China, Louisiana Hope Research Grant provided by Free to Breathe. We thank Alison Kriegel for reading and commenting on the manuscript.

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Author notes

  1. H Zhang, Y Lu and E Chen: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Pathology, School of Medicine, Zhejiang University, Hangzhou, China

    H Zhang

  2. Department of Gynecologic Oncology, The Affiliated Women’s Hospital and Institute for Translational Medicine, School of Medicine, Zhejiang University, Hangzhou, China

    Y Lu & B Lv

  3. Division of Respiratory Medicine, Sir Run Run Shaw Hospital and Institute for Translational Medicine, School of Medicine, Zhejiang University, Hangzhou, China

    E Chen, X Li & P Liu

  4. Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA

    H G Vikis

  5. Department of Physiology and Cancer Center, Medical College of Wisconsin, Milwaukee, WI, USA

    P Liu

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  1. H Zhang
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Correspondence to P Liu.

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Zhang, H., Lu, Y., Chen, E. et al. XRN2 promotes EMT and metastasis through regulating maturation of miR-10a. Oncogene 36, 3925–3933 (2017). https://doi.org/10.1038/onc.2017.39

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