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Preclinical and clinical evaluation of MET functions in cancer cells and in the tumor stroma

Oncogene volume 35, pages 5457–5467 (2016)Cite this article

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Abstract

A lot of attention has been dedicated to investigate the role of the tyrosine kinase receptor MET in tumors. The acquired notion that cancer cells from different histological origin strictly rely on the engagement of this specific oncogene for their growth and survival has certainly justified the development and the use of MET-targeted therapies in the clinic. However, the function and involvement of this pathway in the stroma (that often constitutes >50% of the global cellularity of the tumor) may offer the opportunity to conceive new patient stratification criteria, rational drug design and guided trials of new combination treatments. In this review, we will summarize and discuss the role of MET in cancer cells but especially in different stromal compartments, in light of the results showed by past and recent preclinical and clinical trials with anti-MET drugs.

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Acknowledgements

We thank Sandy Smets for administrative support. MM is holding an ERC Starting Grant (OxyMO). VF is supported by Télévie F.R.S.-FNRS.

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Authors and Affiliations

  1. Ludwig Institute for Cancer Research, Brussels, Belgium

    V Finisguerra

  2. de Duve Institute, Université catholique de Louvain, Brussels, Belgium

    V Finisguerra

  3. University Hospitals Leuven and Department of Oncology, Digestive Oncology, KU Leuven, Leuven, Belgium

    H Prenen

  4. Lab of Molecular Oncology and Angiogenesis, Vesalius Research Center, VIB, Leuven, Belgium

    M Mazzone

  5. Department of Oncology, Lab of Molecular Oncology and Angiogenesis, Vesalius Research Center, KU Leuven, Leuven, Belgium

    M Mazzone

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Finisguerra, V., Prenen, H. & Mazzone, M. Preclinical and clinical evaluation of MET functions in cancer cells and in the tumor stroma. Oncogene 35, 5457–5467 (2016). https://doi.org/10.1038/onc.2016.36

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