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Emerging strategies for cancer immunoprevention

Oncogene volume 34, pages 6029–6039 (2015)Cite this article

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Abstract

The crucial role of the immune system in the formation and progression of tumors has been widely accepted. On one hand, the surveillance role of the immune system plays an important role in endogenous tumor prevention, but on the other hand, in some special circumstances such as in chronic inflammation, the immune system can actually contribute to the formation and progression of tumors. In recent years, there has been an explosion of novel targeted immunotherapies for advanced cancers. In the present manuscript, we explore known and potential various types of cancer prevention strategies and focus on nonvaccine-based cancer preventive strategies targeting the immune system at the early stages of tumorigenesis.

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Acknowledgements

This work was supported by 2014 Pancreatic Cancer Action Network-AACR Career Development Award, grant 14-20-25-MCAL.

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Authors and Affiliations

  1. Department of Oncology. Johns Hopkins University, Maryland, MD, USA

    J C Roeser

  2. The David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    S D Leach

  3. Department of Clinical Cancer Prevention. The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    F McAllister

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Roeser, J., Leach, S. & McAllister, F. Emerging strategies for cancer immunoprevention. Oncogene 34, 6029–6039 (2015). https://doi.org/10.1038/onc.2015.98

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