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Somatic gene copy number alterations in colorectal cancer: new quest for cancer drivers and biomarkers

Oncogene volume 35, pages 2011–2019 (2016)Cite this article

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Abstract

Colorectal cancer (CRC) results from the accumulation of genetic alterations, and somatic copy number alterations (CNAs) are crucial for the development of CRC. Genome-wide survey of CNAs provides opportunities for identifying cancer driver genes in an unbiased manner. The detection of aberrant CNAs may provide novel markers for the early diagnosis and personalized treatment of CRC. A major challenge in array-based profiling of CNAs is to distinguish the alterations that play causative roles from the random alterations that accumulate during colorectal carcinogenesis. In this view, we systematically discuss the frequent CNAs in CRC, focusing on functional genes that have potential diagnostic, prognostic and therapeutic significance.

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Abbreviations

CNA:

copy number alteration

CRC:

colorectal cancer

Chr:

chromosome

mtDNA:

mitochondrial DNA

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Acknowledgements

This project was supported by grants from the National Natural Science Foundation of China (30971330, 31371420, 81320108024, 81000861, 81322036 and 81272383); Foundation for Innovative Research Groups of the National Natural Science Foundation of China (Grant No. 81421001), the Program for Innovative Research Team of Shanghai Municipal Education Commission; Shanghai ‘Oriental Scholars’ project (2013XJ); Shanghai Science and Technology Commission ‘Pujiang Project’ (13PJ1405900); and Shanghai Natural Science Foundation (12ZR1417900). The sponsors of this study had no role in the analysis and interpretation of the literatures, the decision to submit the manuscript for publication or the writing of the manuscript.

Author Contributions

HW, LL, J-YF and JX wrote the paper. JX conceived this work and generated the schematic representation.

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Authors and Affiliations

  1. State Key Laboratory for Oncogenes and Related Genes; Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University; Shanghai Cancer Institute, Shanghai Institute of Digestive Disease,

    H Wang, L Liang, J-Y Fang & J Xu

  2. Key Laboratory of Gastroenterology & Hepatology, Ministry of Health, Shanghai, China

    H Wang, L Liang, J-Y Fang & J Xu

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  1. H Wang
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  2. L Liang
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Correspondence to J Xu.

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Wang, H., Liang, L., Fang, JY. et al. Somatic gene copy number alterations in colorectal cancer: new quest for cancer drivers and biomarkers. Oncogene 35, 2011–2019 (2016). https://doi.org/10.1038/onc.2015.304

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