Figure 6

From: Par6G suppresses cell proliferation and is targeted by loss-of-function mutations in multiple cancers

Figure 6

Genetic alterations affecting PARD6B and PARD6G in human cancer. (a) Mutation and expression status of PARD6B in six cancer types. The status of both PARD6B and PARD6G was analyzed across 14 different cancer types and all cancer types allowing comparison of PARD6B and PARD6G are shown (data exist for both genes at least in two databases; full analysis is shown in Supplementary Figure S3F). Highlighted with red are gain-of-function-type mutations (mRNA upregulation, DNA amplification and gain of copy number) present in 10% of the analyzed samples. Highlighted with blue are loss-of-function changes (downregulation, mutation, deletion, loss of heterozygosity and copy number loss) present in 10% of the analyzed samples. (b) cBioPortal analysis of the status of PARD6B in cancer genomics data sets. (c) Mutation and expression status of PARD6G in six cancer types. The analyses were performed as in panel (a). (d) cBioPortal (Memorial Sloan Kettering Cancer Center) analysis of the status of PARD6G in cancer genomics data sets.