Figure 1

From: Par6G suppresses cell proliferation and is targeted by loss-of-function mutations in multiple cancers

Figure 1

Identification of epithelial structure regulating genes with tumor-suppressor function. (a) hEIR genes with high score for tumor-suppressor properties. All human genes, including hEIR genes, were ranked according to evidence for inactivating type of genetic alterations in cancer using the TSP algorithm. Left side of the column shows the rank and score for three classical TSGs and the right side shows hEIR genes with the highest rank and score. (b) Venn diagram indicating all human genes above the tumor-suppressor value threshold (1252), hEIR genes (77) and the overlapping genes (15). (c) A workflow illustrating the throughput of genes and shRNA constructs at different stages of the screen and the assay end points.