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RACK1, a versatile hub in cancer

Oncogene volume 34, pages 18901898 (09 April 2015) | Download Citation

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Abstract

RACK1 is a highly conserved intracellular adaptor protein with significant homology to Gβ and was originally identified as the anchoring protein for activated protein kinase C. In the past 20 years, the number of binding partners and validated cellular functions for RACK1 has increased, which facilitates clarification of its involvement in different biological events. In this review, we will focus on its role in cancer, summarizing its aberrant expression, pro- or anti-oncogenic effects and the underlying mechanisms in various cancers.

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Acknowledgements

This work was supported by the National Basic Research Program of China (2010CB912102), Ministry of Science and Technology Key Program (2012ZX10002009-017), the National Natural Science Foundation of China (81230058, 30930023, 31100551, 31201046, 81021002), CAS/SAFEA International Partnership Program for Creative Research Teams, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (SIBS2012004) and Technology Commission of Shanghai Municipality (12XD1405600) to DX. This work was also supported by the Young Scientist Fund of National Science Foundation of China (31201046) and Sanofi-Aventis-Sibs Scholarship Program (2011) to J-JL.

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Affiliations

  1. Center for Cancer Research, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, PR China

    • J-J Li
    •  & D Xie

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The authors declare no conflict of interest.

Corresponding author

Correspondence to D Xie.

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DOI

https://doi.org/10.1038/onc.2014.127

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