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Renal disease appears not to affect carcinogenesis in CD151-null mice

Oncogene volume 32, page 4458 (2013)Cite this article

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As published in Oncogene,1 CD151 null mice were backcrossed four generations onto the FVB/N genetic background to increase chemical carcinogenesis sensitivity.2 Although CD151-null mice can have substantial kidney pathology in the FVB/N background,3, 4 we are confident that kidney pathology is not a major confounding issue in our studies of CD151 in a skin chemical carcinogenesis model,1 and in an ErbB2 transgene expression model.5

Second, CD151 effects on tumor formation appear to be independent of kidney pathology. Kidney pathology was not observed in CD151+/− mice3 (and also see Supplementary Figure W2 in Deng et al.5). Nonetheless, CD151+/− mice show a significant delay in tumor appearance, comparable to the delay seen in CD151−/− mice (Figure 1). CD151+/− mice also showed marked reduction in spontaneous metastasis, though not quite to the same extent as CD151−/− mice (see Figure 2a in Deng et al.5). In the chemical carcinogenesis model,1 CD151+/− mice, compared to wild-type mice, showed significantly reduced tumor multiplicity and significantly diminished progression to squamous cell carcinoma. Clearly, these effects on tumor appearance, metastasis and progression caused by loss of one CD151 allele cannot be attributed to kidney pathology. Reinforcing this point, the mean time until ErbB2-driven tumor appearance for two CD151-null mice with kidney pathology (422 days—samples analyzed in Supplementary Figure W2, panels D, E; Deng et al.5) was nearly identical to the mean time until tumor appearance for eight CD151-null mice with minimal pathology (mean 430 days).

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References

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Authors and Affiliations

  1. Dana-Farber Cancer Institute, Boston, MA, USA

    M E Hemler & Q Li

  2. Chandler Medical Center, University of Kentucky, Lexington, KY, USA

    J Hoff & X H Yang

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  1. M E Hemler
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  2. J Hoff
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  3. Q Li
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  4. X H Yang
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Correspondence to M E Hemler or X H Yang.

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Hemler, M., Hoff, J., Li, Q. et al. Renal disease appears not to affect carcinogenesis in CD151-null mice. Oncogene 32, 4458 (2013). https://doi.org/10.1038/onc.2013.79

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