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The role of miR-150 in normal and malignant hematopoiesis

Oncogene volume 33, pages 3887–3893 (2014)Cite this article

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Abstract

MicroRNAs are a class of small non-coding RNAs that have been implicated to mediate gene regulation in virtually all important biological processes. Recently there is accumulating evidence showing that miR-150 has essential regulatory roles in both normal and malignant hematopoiesis and holds great potential as a therapeutic target in treating various types of hematopoietic malignancies. The purpose of this review is to summarize our current knowledge about the expression patterns, biological functions and regulatory mechanisms of miR-150 in normal and malignant hematopoiesis, and to highlight the important questions to be answered in this burgeoning field.

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Acknowledgements

This work was supported in part by the National Institutes of Health (NIH) R01 grant CA127277 (JC), American Cancer Society (ACS) Research Scholar grant (JC), The University of Chicago Committee on Cancer Biology (CCB) Fellowship Program (YH; XJ), and Gabrielle’s Angel Foundation for Cancer Research (JC; XJ).

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  1. Committee on Cancer Biology, University of Chicago, Chicago, IL, USA

    Y He, X Jiang & J Chen

  2. Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL, USA

    X Jiang & J Chen

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Correspondence to J Chen.

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He, Y., Jiang, X. & Chen, J. The role of miR-150 in normal and malignant hematopoiesis. Oncogene 33, 3887–3893 (2014). https://doi.org/10.1038/onc.2013.346

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