Figure 8

From: Desmoglein 3 promotes cancer cell migration and invasion by regulating activator protein 1 and protein kinase C-dependent-Ezrin activation

Figure 8

A model illustrating that Dsg3 acts as an upstream regulator for the Ezrin phosphorylation at Thr567 (activation) through the PKC/AP-1regulation pathway that is required for promoting membrane projections, cell spreading and invasive motility in tumor cells.