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Protein lysine acetylation guards metabolic homeostasis to fight against cancer

Oncogene volume 33, pages 2279–2285 (2014)Cite this article

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Abstract

Properly coordinated metabolism and maintained metabolite homeostasis are important because altered metabolite homeostasis has a causal role in many human diseases, including cancer. Metabolite homeostasis is maintained by fine-tuned coordination of metabolite generation and utilization. Metabolite deregulation has recently been shown to alter the signaling pathways and reprogram epigenetic factors associated with tumorigenesis. Protein lysine acetylation is emerging as a metabolism-coordinating mechanism. Mechanistic studies have shown that acetylation may have roles in nutrient adaptation and in maintaining metabolite homeostasis by exerting regulatory effects on metabolic enzymes, metabolic pathways and metabolic networks. Here we review recent progress in the determination of the role of acetylation regulation in metabolism coordination. In particular, we review links between deregulated acetylation in metabolic enzymes and tumorigenesis. We further hypothesize on applications of the mediation of acetylation to restore deregulated metabolism coordination and thus develop novel means of cancer treatment.

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Acknowledgements

The work was supported by the National 973 Programs of China (Nos. 2012CB910300, 2012CB721102, 2013CB911204 and 2013CB945400), NSFC Foundation of China (31030042) and the Shanghai Basic Research Fund (11JC1401100).

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  1. Sate Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, People’s Republic of China

    W Xu, Y Li, C Liu & S Zhao

  2. Institutes of Biomedical Sciences, Fudan University, Shanghai, People’s Republic of China

    W Xu & S Zhao

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Xu, W., Li, Y., Liu, C. et al. Protein lysine acetylation guards metabolic homeostasis to fight against cancer. Oncogene 33, 2279–2285 (2014). https://doi.org/10.1038/onc.2013.163

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