Table 1 Tumor growth and metastasis in mice bearing human breast cancer xenografts +/− co-mixed mammary fibroblasts

From: The role of fibroblast Tiam1 in tumor cell invasion and metastasis

  No. of mice with tumors/total mice (no. of tumors) (P-value) No. of weeks until measurable tumor (s.d.) (P-value) No. of mice with detectable lung mets/no. of evaluable lungs (P-value)
SUM1315 10/10 (16) (—) 10.8 (1.4) (—) 4/8 (—)
SUM1315+control RMF 8/10 (8) (P=0.66) 17.1 (2.0) (P=0.000006) 0/7 (P=0.03)
SUM1315+shTiam RMF 8/10 (12) (P=0.66) 15.8 (2.9) (P=0.0006) 5/10 (P=1.0)
  1. Abbreviations: RMF, reduction mammary fibroblast; sh, short hairpin.