Figure 4 | Oncogene

Figure 4

From: Lipocalin 2 is required for BCR-ABL-induced tumorigenesis

Figure 4

Overexpression of human lipocalin 2 (NGAL) in K562 causes suppression of hematopoiesis. (a) Western blot showing overexpression of NGAL in K562 cells. (b) Irradiated mice (250 cGy) receiving K562 cells overexpressing NGAL have reduced spleens. Lower panel is the quantitation of the spleen weight. (c) Top panel, H&E staining of spleens from normal mice (irradiated) (left), mice injected with K562 transfected with vector alone (middle) and mice injected with K562 overexpressing NGAL (left) at 45 days post cell inoculation. ‘at’ marks atrophy. Bottom panel is the immunohistochemical staining of cleaved caspase 3 (brown spots).

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