Figure 2 | Nutrition & Diabetes

Figure 2

From: The cannabinoid Δ9-tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in two mouse models of obesity

Figure 2

Effect of THCV on glucose tolerance and indexes of insulin sensitivity in DIO mice (study 1). (a) Glucose tolerance after 7 days treatment with AM251 or THCV, n=9 mice per treatment. (b) Blood glucose concentration in 5-h fasted mice after 7 days treatment with AM251 or THCV, n=9 mice per treatment. (c) Plasma insulin in 5-h fasted mice and at 30 min post glucose load after 7 days treatment with AM251 or THCV, n=9 mice per treatment. (d) Homeostatic model assessment (HOMA) index (glucose × insulin) in 5-h fasted mice after 7 days treatment with AM251 or THCV. (e) Glucose tolerance after 3 weeks treatment with AM251 or THCV, n=9 mice per treatment. (f) Plasma insulin in 5-h fasted mice at 30 min post glucose load after 3 weeks treatment with AM251 or THCV, n=9 mice per treatment. (g) HOMA index (glucose × insulin) in 5-h fasted mice after 3 weeks treatment with AM251 or THCV. (h) HOMA index (glucose × insulin) at 30 min post glucose load after 3 weeks treatment with AM251 or THCV. *P<0.05; **P<0.01 as compared to vehicle treated animals.

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