Abstract
The major polyphenol in green tea, (−)-epigallocatechin-3-gallate (EGCG), has been shown to prevent carcinogenesis. We have identified a receptor that mediates the anticancer activity of EGCG. Expression of the metastasis-associated 67-kDa laminin receptor confers EGCG responsiveness to cancer cells at physiologically relevant concentrations. Experiments using surface plasmon resonance demonstrate binding of EGCG to the 67-kDa laminin receptor with a nanomolar K d value.
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Acknowledgements
We thank T. Shimomura for helpful discussions. We thank M. Sumida and C. Tahara for technical assistance. This work was supported in part by grants from Bio-oriented Technology Research Advancement Institution and from Integrated Research on Safety and Physiological Function of Food, MAFF, Japan, to H.T.
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Tachibana, H., Koga, K., Fujimura, Y. et al. A receptor for green tea polyphenol EGCG. Nat Struct Mol Biol 11, 380–381 (2004). https://doi.org/10.1038/nsmb743
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DOI: https://doi.org/10.1038/nsmb743
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