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A receptor for green tea polyphenol EGCG

Abstract

The major polyphenol in green tea, (−)-epigallocatechin-3-gallate (EGCG), has been shown to prevent carcinogenesis. We have identified a receptor that mediates the anticancer activity of EGCG. Expression of the metastasis-associated 67-kDa laminin receptor confers EGCG responsiveness to cancer cells at physiologically relevant concentrations. Experiments using surface plasmon resonance demonstrate binding of EGCG to the 67-kDa laminin receptor with a nanomolar K d value.

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Figure 1: Anticancer action of EGCG is mediated by the 67-kDa laminin receptor.
Figure 2: The interactions between tea constituents and 67 LR–transfected cells.

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Acknowledgements

We thank T. Shimomura for helpful discussions. We thank M. Sumida and C. Tahara for technical assistance. This work was supported in part by grants from Bio-oriented Technology Research Advancement Institution and from Integrated Research on Safety and Physiological Function of Food, MAFF, Japan, to H.T.

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Correspondence to Hirofumi Tachibana.

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Tachibana, H., Koga, K., Fujimura, Y. et al. A receptor for green tea polyphenol EGCG. Nat Struct Mol Biol 11, 380–381 (2004). https://doi.org/10.1038/nsmb743

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