Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Brief Communication
  • Published:

YY1 functions with INO80 to activate transcription

Abstract

Ubiquitously expressed transcription factor Yin-Yang-1 (YY1) controls expression of many genes. YY1 is tightly associated with the human ATP-dependent INO80-like chromatin-remodeling complex (INO80). INO80 is recruited by YY1 to YY1-activated genes, where it functions as an essential coactivator. Binding of YY1 to its DNA sites in target genes requires INO80, suggesting that YY1 uses the INO80 complex not only to activate transcription but also to gain access to target promoters.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: YY1 is associated with INO80.
Figure 2: INO80 functions as a coactivator for YY1-activated genes.

Similar content being viewed by others

References

  1. Jin, J. et al. J. Biol. Chem. 280, 41207–41212 (2005).

    Article  CAS  Google Scholar 

  2. Shen, X., Mizuguchi, G., Hamiche, A. & Wu, C. Nature 406, 541–544 (2000).

    Article  CAS  Google Scholar 

  3. Liu, H.F. & Shi, Y. in Zinc Finger Proteins: From Atomic Contact to Cellular Function (eds. Iuchi, S. & Kuldell, N.) 182–194 (Landes Bioscience and Kluwer Academic Press, Georgetown and New York, 2005).

    Book  Google Scholar 

  4. Affar, el B. et al. Mol. Cell. Biol. 26, 3565–3581 (2006).

    Article  Google Scholar 

  5. Rezai-Zadeh, N. et al. Genes Dev. 17, 1019–1029 (2003).

    Article  CAS  Google Scholar 

  6. Thomas, M.J. & Seto, E. Gene 236, 197–208 (1999).

    Article  CAS  Google Scholar 

  7. Klymenko, T. et al. Genes Dev. 20, 1110–1122 (2006).

    Article  CAS  Google Scholar 

  8. Schlisio, S., Halperin, T., Vidal, M. & Nevins, J.R. EMBO J. 21, 5775–5786 (2002).

    Article  CAS  Google Scholar 

  9. Li, J. & Lee, A.S. Curr. Mol. Med. 6, 45–54 (2006).

    Article  CAS  Google Scholar 

  10. Baumeister, P. et al. Mol. Cell. Biol. 25, 4529–4540 (2005).

    Article  CAS  Google Scholar 

  11. Li, W.W., Alexandre, S., Cao, X. & Lee, A.S. J. Biol. Chem. 268, 12003–12009 (1993).

    CAS  PubMed  Google Scholar 

  12. Atchison, L., Ghias, A., Wilkinson, F., Bonini, N. & Atchison, M.L. EMBO J. 22, 1347–1358 (2003).

    Article  CAS  Google Scholar 

  13. Paredes, R. et al. Biochem. J. 363, 667–676 (2002).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was supported in part by US National Institutes of Health grant R37GM41628 (to R.C.C.).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Joan W Conaway.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Supplementary information

Supplementary Text and Figures

Supplementary Figures 1–5, Supplementary Table 2, Supplementary Methods (PDF 410 kb)

Supplementary Table 1

Supplementary Table 1 (XLS 41 kb)

Supplementary Table 3

Supplementary Table 3 (XLS 998 kb)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cai, Y., Jin, J., Yao, T. et al. YY1 functions with INO80 to activate transcription. Nat Struct Mol Biol 14, 872–874 (2007). https://doi.org/10.1038/nsmb1276

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsmb1276

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing