Abstract
Ubiquitously expressed transcription factor Yin-Yang-1 (YY1) controls expression of many genes. YY1 is tightly associated with the human ATP-dependent INO80-like chromatin-remodeling complex (INO80). INO80 is recruited by YY1 to YY1-activated genes, where it functions as an essential coactivator. Binding of YY1 to its DNA sites in target genes requires INO80, suggesting that YY1 uses the INO80 complex not only to activate transcription but also to gain access to target promoters.
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References
Jin, J. et al. J. Biol. Chem. 280, 41207–41212 (2005).
Shen, X., Mizuguchi, G., Hamiche, A. & Wu, C. Nature 406, 541–544 (2000).
Liu, H.F. & Shi, Y. in Zinc Finger Proteins: From Atomic Contact to Cellular Function (eds. Iuchi, S. & Kuldell, N.) 182–194 (Landes Bioscience and Kluwer Academic Press, Georgetown and New York, 2005).
Affar, el B. et al. Mol. Cell. Biol. 26, 3565–3581 (2006).
Rezai-Zadeh, N. et al. Genes Dev. 17, 1019–1029 (2003).
Thomas, M.J. & Seto, E. Gene 236, 197–208 (1999).
Klymenko, T. et al. Genes Dev. 20, 1110–1122 (2006).
Schlisio, S., Halperin, T., Vidal, M. & Nevins, J.R. EMBO J. 21, 5775–5786 (2002).
Li, J. & Lee, A.S. Curr. Mol. Med. 6, 45–54 (2006).
Baumeister, P. et al. Mol. Cell. Biol. 25, 4529–4540 (2005).
Li, W.W., Alexandre, S., Cao, X. & Lee, A.S. J. Biol. Chem. 268, 12003–12009 (1993).
Atchison, L., Ghias, A., Wilkinson, F., Bonini, N. & Atchison, M.L. EMBO J. 22, 1347–1358 (2003).
Paredes, R. et al. Biochem. J. 363, 667–676 (2002).
Acknowledgements
This work was supported in part by US National Institutes of Health grant R37GM41628 (to R.C.C.).
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Cai, Y., Jin, J., Yao, T. et al. YY1 functions with INO80 to activate transcription. Nat Struct Mol Biol 14, 872–874 (2007). https://doi.org/10.1038/nsmb1276
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DOI: https://doi.org/10.1038/nsmb1276
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