A recent report shows that several 'poly-ADP-ribose-polymerases' may function exclusively as a family of endogenous mono-ADP-ribosyltransferases, providing a new, molecularly less complex and broadened cellular role for this elusive post-translational modification.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Walsh, C.T. Posttranslational Modification of Proteins: Expanding Nature's Inventory (Roberts, Greenwood Village, Colorado, USA, 2006).
Krueger, K.M. & Barbieri, J.T. Clin. Microbiol. Rev. 8, 34–47 (1995).
Ueda, K. & Hayaishi, O. Annu. Rev. Biochem. 54, 73–100 (1985).
Lupi, R., Corda, D. & Di Girolamo, M. J. Biol. Chem. 275, 9418–9424 (2000).
Hassa, P.O. & Hottiger, M.O. Front. Biosci. 13, 3046–3082 (2008).
Liszt, G., Ford, E., Kurtev, M. & Guarente, L. J. Biol. Chem. 280, 21313–21320 (2005).
Kleine, H. et al. Mol. Cell 32, 57–69 (2008).
Yu, M. et al. Oncogene 24, 1982–1993 (2005).
Allis, C.D., Jenuwein, T. & Reinberg, D. Epigenetics (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, USA, 2007).
Liou, G.G., Tanny, J.C., Kruger, R.G., Walz, T. & Moazed, D. Cell 121, 515–527 (2005).
Huse, M. & Kuriyan, J. Cell 109, 275–282 (2002).
Karras, G.I. et al. EMBO J. 24, 1911–1920 (2005).
Kustatscher, G., Hothorn, M., Pugieux, C., Scheffzek, K. & Ladurner, A.G. Nat. Struct. Mol. Biol. 12, 624–625 (2005).
Dhalluin, C. et al. Nature 399, 491–496 (1999).
Jacobson, R.H., Ladurner, A.G., King, D.S. & Tjian, R. Science 288, 1422–1425 (2000).
Acknowledgements
K.D. is funded by the European Union FP6 Marie Curie Research and Training Network “Chromatin Plasticity”. S.T. and K.D. are students in the European Molecular Biology Laboratory's International PhD Programme. A.G.L. acknowledges the financial support of the European Molecular Biology Laboratory.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Till, S., Diamantara, K. & Ladurner, A. PARP: a transferase by any other name. Nat Struct Mol Biol 15, 1243–1244 (2008). https://doi.org/10.1038/nsmb1208-1243
Issue Date:
DOI: https://doi.org/10.1038/nsmb1208-1243
This article is cited by
-
Functions of the poly(ADP-ribose) polymerase superfamily in plants
Cellular and Molecular Life Sciences (2012)
-
Endogenous protein mono-ADP-ribosylation in Arabidopsis thaliana
Planta (2011)